AI-guided neuromodulation

Combining the power of biologically-inspired models and contemporary statistics

A natural outcome of building models whose internal representations mirror biological mechanisms is that they can serve as functional blueprints for neuroprosthetics and other neurotechnologies. I’ve had the opportunity to design AI pipelines that guide in vivo neuromodulation in a fully automated, data-driven, and rapid way. I’m very excited about this growing body of work (Govindarajan et al., 2022; Parker et al., 2025; Calvert et al., 2026).

References

2026

Nature BME

Perilesional neuromodulation replaces lost sensorimotor function in persons with spinal cord injury

Jonathan Calvert, Samuel R. Parker, Lakshmi Narasimhan Govindarajan, Radu Darie, Elias Shaaya, and 20 more authors

Nature Biomedical Engineering, 2026

Bib HTML PDF

@article{calvert2025perilesional,
  title = {Perilesional neuromodulation replaces lost sensorimotor function in persons with spinal cord injury},
  author = {Calvert, Jonathan and Parker, Samuel R. and Govindarajan, Lakshmi Narasimhan and Darie, Radu and Shaaya, Elias and Solinsky, Ryan and Del Valle, Lily M. and Miranda, Priyanka and Jang, Jaeson and Tiwari, Ekta and Syed, Sohail and Villalobos, Raymond M. and Aguiar, Liza M. and Taylor, Andrew J. and Tang, Hanlin and McPherson, Sean and Xue, Wenzhe and Carayannopoulos, Alexios G. and Oyelese, Adetokunbo A. and Gokaslan, Ziya L. and Bansal, Arjun K. and Resnik, Linda J. and Serre, Thomas and Fridley, Jared S. F and Borton, David A.},
  journal = {Nature Biomedical Engineering},
  year = {2026},
}

2025

J. Neural Eng.

An active electronic, high-density epidural paddle array for chronic spinal cord neuromodulation

Samuel R Parker, Jonathan S Calvert, Radu Darie, Jaeson Jang, Lakshmi Narasimhan Govindarajan, and 6 more authors

Journal of Neural Engineering, 2025

2022

J. Neural Eng.

Fast inference of spinal neuromodulation for motor control using amortized neural networks

Lakshmi Narasimhan Govindarajan, Jonathan S Calvert, Samuel R Parker, Minju Jung, Radu Darie, and 4 more authors

Journal of neural engineering, 2022